2005 depauw baseball schedule/results (29-14, 12-4 SCAC)
| Date | Opponent | Time/Score |
| Feb. 22 | at Indiana | L, 0-5 |
| Feb. 26 | ANDERSON | L, 1-2 (9) |
| ANDERSON | W, 5-2 | |
| Feb. 27 | at Transylvania | W, 4-3 |
| March 4 | HOPE | W, 6-3 |
| HOPE | W, 9-4 | |
| March 5 | BENEDICTINE | W, 6-1 |
| March 6 | BLACKBURN | W, 7-6 |
| BLACKBURN | L, 6-7 (11) | |
| March 13 | MANCHESTER | L, 2-3 (8) |
| MANCHESTER | L, 2-6 | |
| March 15 | WABASH | W, 5-0 |
| March 16 | at Wabash | W, 11-1 |
| March 18 | *OGLETHORPE | W, 12-2 |
| March 19 | *OGLETHORPE | W, 9-5 |
| *OGLETHORPE | W, 8-1 | |
| March 20 | *OGLETHORPE | L, 7-8 |
| March 21 | vs. Carthage at Port Charlotte, Fla. | L, 6-8 (11) |
| March 22 | vs. Chicago at Port Charlotte, Fla. | W, 13-6 |
| March 24 | vs. Elmhurst at Port Charlotte, Fla. | W, 11-1 |
| March 25 | *at Sewanee | W, 15-11 |
| *at Sewanee (game finished on 3/26) | L, 4-5 | |
| March 26 | *at Sewanee | W, 8-2 |
| *at Sewanee | W, 6-3 | |
| March 31 | FRANKLIN | W, 15-4 |
| April 2 | *CENTRE | W, 4-2 |
| *CENTRE | W, 16-0 | |
| April 3 | *CENTRE | W, 10-0 |
| *CENTRE | W, 10-0 | |
| April 6 | at Franklin | L, 9-11 |
| April 8 | *at Rose-Hulman | W, 5-4 |
| April 9 | *at Rose-Hulman | L, 1-4 |
| *at Rose-Hulman | W, 7-5 | |
| April 10 | *at Rose-Hulman | L, 8-21 |
| April 13 | at Mount St. Joseph | W, 6-4 |
| April 16 | WASHINGTON (Mo.) | W, 3-0 |
| WASHINGTON (Mo.) | W, 8-2 | |
| April 21 | vs. Millsaps (SCAC Tournament at Conway, Ark.) | L, 7-16 |
| April 22 | vs. Rose-Hulman (SCAC Tournament at Conway, Ark.) | W, 10-8 |
| April 23 | vs. Southwestern or Trinity (SCAC Tournament at Conway, Ark.) | L, 2-4 |
| April 27 | HANOVER (1-9) | W, 9-8 |
| May 1 | at Thomas More | L, 3-8 |
| at Thomas More | W, 7-3 | |
| Postponed/canceled games:
March 12 vs. Hanover |
||